Chemogenetic manipulation of dopamine neurons dictates cocaine potency at distal dopamine transporters
… We next examined whether selective activation of somatodendritic DREADDs impacts cocaine
potency at distal DATs in the NAc. We implanted bilateral cannulae targeted to the VTA of …
potency at distal DATs in the NAc. We implanted bilateral cannulae targeted to the VTA of …
… , a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 …
… levels such as the type achieved by allosteric targeting of dopamine transporter activity. …
effects on behavior. The normalization of dopamine uptake and extracellular dopamine levels …
effects on behavior. The normalization of dopamine uptake and extracellular dopamine levels …
[HTML][HTML] Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system …
PM Estave, SE Albertson, AN Karkhanis, SR Jones - Scientific Reports, 2024 - nature.com
… 2) reduced effects of cocaine on extracellular DA … attenuating subjective or reinforcing
effects of cocaine 59 , it is possible that phendimetrazine may be successful as part of a dual-target …
effects of cocaine 59 , it is possible that phendimetrazine may be successful as part of a dual-target …
[HTML][HTML] A study of the dopamine transporter using the TRACT assay, a novel in vitro tool for solute carrier drug discovery
HJ Sijben, JJE van den Berg, JD Broekhuis… - Scientific reports, 2021 - nature.com
… -dependent monoamine transporter 23 , is a clinical target for … addictive effects of psychoactive
substances such as cocaine and … extracellular dopamine leading to attenuated dopamine-…
substances such as cocaine and … extracellular dopamine leading to attenuated dopamine-…
Identification of a novel allosteric modulator of the human dopamine transporter
S Aggarwal, X Liu, C Rice, P Menell… - ACS chemical …, 2019 - ACS Publications
… dopaminergic neurotransmission by removing extracellular … , we target a similar region in
DAT that we previously targeted in SERT… attenuated the effects of cocaine at the 30 μM cocaine …
DAT that we previously targeted in SERT… attenuated the effects of cocaine at the 30 μM cocaine …
Allosteric Modulator KM822 Attenuates Behavioral Actions of Amphetamine in Caenorhabditis elegans through interactions with the dopamine transporter DAT-1
… large number of potential off-target sites. Here, we … attenuate the action of psychostimulants
like cocaine and AMPH, reinforcing our decision to examine potential in vivo consequences …
like cocaine and AMPH, reinforcing our decision to examine potential in vivo consequences …
[HTML][HTML] Dynamic control of the dopamine transporter in neurotransmission and homeostasis
M Bu, MJ Farrer, H Khoshbouei - NPJ Parkinson's disease, 2021 - nature.com
… , dopamine can have completely opposing effects on target … reuptake of extracellular
dopamine into the intracellular space. … -mediated DAT internalization is blocked by cocaine which …
dopamine into the intracellular space. … -mediated DAT internalization is blocked by cocaine which …
[图书][B] Functional Studies of a Dopamine Transporter Allosteric Modulator and Its Effect on Cocaine-induced Behavior
Y Xu - 2020 - search.proquest.com
… extracellular dopamine level resulting in euphoria. Although … First, we gave the rats had
cannula implanted targeting the … whether KM822 will attenuate cocaine-induced hyperlocomotion …
cannula implanted targeting the … whether KM822 will attenuate cocaine-induced hyperlocomotion …
[HTML][HTML] Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity
T Sorkina, MH Cheng, TR Bagalkot, C Wallace… - Journal of Biological …, 2021 - ASBMB
… altered dopamine transport kinetics and increased cocaine-… TM4-9 hub a new target for
pharmacological modulation of DAT … reuptake of dopamine from the extracellular space. The …
pharmacological modulation of DAT … reuptake of dopamine from the extracellular space. The …
Calbindin-D28K Limits Dopamine Release in Ventral but Not Dorsal Striatum by Regulating Ca2+ Availability and Dopamine Transporter Function
KR Brimblecombe, S Vietti-Michelina… - ACS chemical …, 2019 - ACS Publications
… (26,36) Given the apparent role for calb1 in determining intracellular Ca 2+ … attenuated
effect of cocaine on peak [DA] o in CalbKD vs CalbWT mice was seen across a range of cocaine …
effect of cocaine on peak [DA] o in CalbKD vs CalbWT mice was seen across a range of cocaine …